WeightWatchers inventory surges after Sequence deal

shares of WW Internationalalso known as WeightWatchers, soared on Tuesday after the company announced it would buy Sequence, a telehealth platform used to treat obesity.

The stock closed 79% higher on Tuesday. Its market value was more than $488 million.

“As the trusted leader in weight management, it is our responsibility to support those interested in finding out if medication is right for them,” WW CEO Sima Sistani said in an announcement Monday.

Tuesday’s jump follows a year of flagging performance for the stock. The company’s shares have fallen 57% over the past year as it struggled to focus on wellness and move away from weight loss.

Sistani took over as CEO in late February and steered the company back toward weight loss.

The Sequence announcement comes as companies in the weight-loss industry seek to offer obesity drugs as a way for customers to shed pounds.

The trend has led to a shortage of drugs like Ozempic, which are commonly prescribed for type 2 diabetes.

Florida stripper arrested after throwing wad of money at ex’s head

An angry one Florida The stripper was arrested last month after allegedly throwing a “large amount of rolled up money” on a colleague’s head, according to a criminal complaint smoking gun.

Tierah Miller29, is accused of assaulting the 34-year-old man she previously dated, who also works as a security guard at the Baby Dolls strip club in Clearwater.

Stripper ‘ambushed’ co-worker/ex-boyfriend with huge wad of cash, criminal charges say

The incident is said to have happened at the club around 11:55am on February 26, just a week after the couple split, the complaint said.

Miller, who appeared sober at the time, allegedly threw a “large” wad of cash at the man after “trying to walk across the stage to speak to another colleague” and hit him in the back of the head.

As she left the club, she intentionally knocked over a stool with the victim’s cell phone, an ID scanner and a metal detector, according to the complaint.

RELATED: Portland woman creates PowerPoint presentation to reveal to her parents she’s a stripper

Her ex-boyfriend said when he found his cellphone in the parking lot, it was broken and it cost an estimated $100 to fix the screen, the complaint continues.

Stripper charged with misdemeanor, victim largely unharmed

The complaint said she was charged with trespassing.

Meanwhile, no blood was shed in the attack and the man sustained no serious injuries.

The exact amount of money thrown at the victim remains unclear, but the outlet reported that “single (dollar bills) appear to be a likely component.”

Miller was released from prison without bail and ordered to refrain from all contact with her ex, but has been allowed to continue dancing at the club where the two are employed.

She was previously convicted of reckless driving, marijuana possession and driving without a license, according to Smoking Gun.

Rivian raises $1.three billion amid considerations about EV demand

The Rivian name is seen on one of their new electric SUV vehicles in San Diego, the United States, on December 16, 2022.

Mike Blake | Reuters

Rivian Automotive plans to raise $1.3 billion in cash through the sale of convertible debentures and join a growing list of electric vehicle manufacturers scrambling to hoard cash when demand slacks.

Rivian shares closed down over 14% on Tuesday.

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Rivian said late Monday it plans to sell the convertible bonds — bonds that can be redeemed for cash, stock or a mix of both — to fund the development and launch of its forthcoming smaller R2 car line, now expected in 2026 . The institutional investors purchasing the Notes will have the option to purchase up to $200 million in additional Notes if they wish, in addition to the initial $1.3 billion.

Rivian isn’t in an urgent liquidity crisis, at least not yet. The EV maker had $12.1 billion on tap at the end of 2022, it said during its fourth-quarter earnings presentation on Feb. 28, enough to fund its operations through 2025. But he recently took a number of measures to save cash, laying off 6% of the workforce and pushing the R2’s launch forward by a year.

Rivian would be facing its final days if it weren't for the Saudi support, says ZoZo Go CEO

Rivian also said last week that it expects to produce 50,000 vehicles in 2023, down from the roughly 60,000 Wall Street analysts had been expecting. That could be a sign that demand for its high-priced pickups and SUVs is falling short of expectations.

ClearAnother startup that makes high-priced electric vehicles also led investors to lower-than-expected production in 2023 and said it plans to ramp up its marketing in the coming months, suggesting it may be less too orders than expected.

Rivian raised nearly $12 billion when it went public in late 2021, helping it amass a cash hoard that still dwarfs most other EV startups. However, the company’s shares have lost over 80% of their value since the debut.

Rivian said the convertible bonds would qualify as “green bonds,” meaning they meet a set of criteria that tend to attract institutions willing to accept lower yields in exchange for supporting sustainable development.

The Notes mature in March 2029. The interest rate and other terms will be determined when the offer is priced.

White Home approves Senate TikTok invoice and urges Congress to move it quickly

U.S. Senator Mark Warner (D-VA) and other U.S. senators unveil legislation that would allow the Biden administration to “ban” foreign tech products like Chinese video app TikTok during a news conference on Capitol Hill in Washington in March or to ban”. 7th, 2023.

Bonnie Cash | Reuters

The White House on Tuesday backed a new bipartisan Senate bill that would give the Biden administration the power to ban TikTok in the US

The legislation would empower the Department of Commerce to review deals, software updates, or data transmissions through information and communications technology in which a foreign adversary has an interest. TikTok, which has become a viral sensation in the US by allowing kids to create and share short videos, is owned by Chinese internet giant ByteDance.

Under the new proposal, if the Commerce Secretary determines a transaction poses an “unreasonable or unacceptable risk” to U.S. national security, it can be referred to the President for action, up to and including a forced divestment.

The bill was dubbed the RESTRICT Act, which stands for Restricting the Emergence of Security Threats that Risk Information and Communications Technology.

Sen. Mark Warner, D-Va., chairman of the Senate Intelligence Committee, formally introduced the legislation on Capitol Hill along with a bipartisan group of Senate co-sponsors. The White House issued a statement publicly endorsing the bill, while Warner briefed reporters.

“This law provides a systematic framework to address technology-based threats to the security of Americans,” said White House national security adviser Jake Sullivan said in a statement, adding that it would provide the government with new tools to mitigate national security risks in the technology sector.

Sullivan urged Congress to “act quickly to send the bill to the President’s desk.”

“Critically, it would strengthen our ability to address discrete risks created by individual transactions and systemic risks created by certain classes of transactions involving countries of concern in sensitive technology sectors,” Sullivan said.

A TikTok spokeswoman did not respond to CNBC’s request for comment on Tuesday.

Sullivan’s statement marks the first time a TikTok bill has received the Biden administration’s explicit support in Congress, and it catapulted Warner’s bill to the top of a growing list of congressional proposals to ban TikTok.

As of Tuesday, Warner’s legislation had not had a companion version in the House. But Warner told CNBC he already has “a lot of interest” from both Democrats and Republicans in the lower chamber.

Warner declined to say who he and Republican co-sponsor Sen. John Thune, RSD, might ask for assistance in the House of Representatives, but added, “I’m very pleased with the keen interest we’ve received from some of ours.” Housemates.”

Earlier this month, the House Foreign Affairs Committee passed a bill that would force the president to impose sanctions on Chinese companies that could potentially leak Americans’ private information to a foreign adversary.

But unlike Warner’s bill, the House legislation known as the DATA Act has no Democratic backers, and it has advanced out of committee along party lines, making its prospects in the Senate with a Democratic majority difficult.

Senators introducing the bill Tuesday stressed that unlike some other proposals, their legislation does not single out individual companies. Instead, it aims to create a new framework and legal process for identifying and mitigating specific threats.

“The RESTRICT Act is about more than just TikTok,” Warner told reporters. “He’s going to give us that comprehensive approach.”

The new Senate bill defines foreign adversaries as the governments of six countries: China, Russia, Iran, North Korea, Venezuela and Cuba. It also says it will apply to information and communications technology services that have at least 1 million active US users per year or that have sold at least 1 million units to US customers in the past year.

That could go far beyond TikTok, which claims it had 100 million monthly active users in the US in 2020

The company came under scrutiny by the US Committee on Foreign Relations following ByteDance’s 2017 acquisition of Musical.ly, a precursor to the popular video-sharing app.

But that process has stalled, and lawmakers and administration officials are impatient to address what they see as a critical national security risk. TikTok has claimed that CFIUS approval of a new risk mitigation strategy is the best way forward.

“The Biden administration does not need additional powers from Congress to address national security concerns related to TikTok: it can approve the deal negotiated with CFIUS over two years, which it has been reviewing for the past six months,” said Brooke Oberwetter, spokeswoman for TikTok, in a statement before the text of the law was released.

“A US ban on TikTok is a ban on the export of American culture and values ​​to the more than 1 billion people who use our service worldwide,” the company said. “We hope Congress will seek solutions to their national security concerns that do not result in the voices of millions of Americans being censored.”

Will Farrell, TikTok’s interim security officer, described in a speech Monday the multi-pronged approach the company plans to take to mitigate the risk that the Chinese government could disrupt its operations in the United States

The so-called Project Texas would be involved in this oracle hosts its data in the cloud with strict procedures on how that information can be accessed and even sends verified code directly to the mobile app stores where users can find the service.

Farrell said TikTok’s commitments would result in an “unprecedented level of transparency” for such a tech company.

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WATCH: TikTok Ban Law: What you need to know

California Gov. Newsom says the state is not going to do enterprise with Walgreens

California Gov. Gavin Newsom successfully defeated a recall attempt in California last year. When asked if he was preparing to run for president, Newsom insisted he wasn’t.

Justin Sullivan | Getty Images

California Gov. Gavin Newsom said Monday the state would no longer do business with him Walgreensafter the drugstore chain told 21 Republican attorneys general it would not sell the abortion pill in its states.

Newsom said on Twitter that the state was “done” with dealings with Walgreens. Brandon Richards, a spokesman for the governor, said California is reviewing all of Walgreens’ relationships with the state.

“We will not do business with companies that give in to right-wing bullies who are pushing their extremist agenda, or companies that prioritize politics over women’s and girls’ health,” Richards said.

According to a statement, Walgreens plans to sell mifepristone “in every jurisdiction where it is legally permitted to do so.” “Once we are FDA certified, we will be distributing this drug in accordance with federal and state laws,” the company added.

The Food and Drug Administration in January allowed retail pharmacies to sell the abortion pill mifepristone if they are certified under an agency program that oversees how the drug is used and distributed.

Walgreens plans to become certified to sell mifepristone where legal under state and federal law, the company said. In February, 21 Republican attorneys general warned Walgreens not to ship mifepristone in their states.

Join us for CNBC’s Healthy Returns on March 29, where we’re hosting a virtual gathering of healthcare CEOs, scientists, investors and innovators to reflect on the advances made today in reinventing the future of medicine. We also have an exclusive look at the best investment opportunities in biopharma, healthcare technology and managed care. Learn more and register today: http://bit.ly/3DUNbRo

The company told attorneys general it would not sell or ship the pill in their states. Politico first reported the news.

Mifepristone, used in combination with another drug called misoprostol, is the most common method of abortion in the United States, accounting for about half of all abortions.

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Mifepristone has become a central issue in the fight for access to abortion after the Supreme Court’s Roe v. Wade had picked up.

A group of anti-abortion doctors have petitioned a Texas federal court to stay the FDA’s approval of mifepristone. On the other hand, Democratic attorneys general have asked a federal court in Washington to declare the FDA’s remaining restrictions on mifepristone unconstitutional.

The FDA approved mifepristone more than two decades ago, but the agency has imposed restrictions to ensure the pill’s safe use. The agency has gradually eased these restrictions over the years as more evidence of their safety and effectiveness accumulates.

The agency removed the requirement for patients to receive the pill in person at certain health facilities and allowed the drugs to be mailed. Patients still need a prescription from a healthcare provider that is FDA certified.

This operating jacket from Amazon with over 7,600 5-star critiques is now on sale

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Alec Baldwin ‘Rust’ prosecutors slammed for missteps

Actor Alec Baldwin leaves his home as he faces involuntary manslaughter charges in the fatal shooting of cinematographer Halyna Hutchins on the set of the film ‘Rust’ January 31, 2023 in New York.

David Dee Delgado | Reuters

It’s been a little over a month since New Mexico authorities charged Alec Baldwin with manslaughter for fatally shooting a crew member on the set of the film Rust, and already prosecutors have come under fire and scrutiny.

First of all, the question arises as to whether the chief prosecutor is even entitled to hear the case. The state constitution prohibits a member of one branch of government from exercising power in another branch. Andrea Reeb, the special prosecutor, also serves as the Republican legislature. Baldwin’s attorneys filed a motion on February 7 to have Reeb removed from the case.

The Reeb and New Mexico prosecutors denied that disqualification motion, calling the defense’s argument a “misunderstanding” and saying it rests “on a novel theory that has no support in the statutes or jurisprudence of New Mexico,” according to those filing Court documents Monday.

“Accepting the defendant’s theory would require the court to enact new legislation that would have nationwide implications and be based on nothing more than creative, unsupported arguments,” prosecutors wrote in the court filings.

Legal experts have also criticized Reeb for overcharging Baldwin based on a law that wasn’t in effect at the time of the fatal shooting. She relented and downgraded the charges, which could result in a shorter prison sentence for Baldwin if convicted.

Lawyers also found inflammatory press statements and media appearances by prosecutors strange, as prosecutors are usually advised to save their comments for the courtroom.

“From the beginning, there were some unusual facts surrounding the prosecution’s prosecution,” said John Day, a Santa Fe-based attorney who has practiced law in New Mexico since 1996.

The charges stem from the October 2021 shooting of cinematographer Halyna Hutchins while filming independent film Rust. Baldwin, who also starred in The Departed and Beetlejuice, held the gun, which was loaded with live ammunition.

Baldwin, who is also a producer of Rust, and the film’s gunsmith at the time, Hannah Gutierrez-Reed, were both charged in January by New Mexico First Circuit Attorney Mary Carmack-Altwies with two separate counts of involuntary manslaughter. By law, a jury can only convict her on one of those charges, each of which carries a maximum possible sentence of 18 months in prison.

David Halls, the film’s first assistant director, signed an agreement to plead charges of negligent use of a deadly weapon and receive a suspended sentence and six months’ probation.

Baldwin and Gutierrez-Reed are scheduled to appear virtually for a status hearing on Thursday.

The Special Prosecutor

Carmack-Altwies appointed Reeb as a special prosecutor in August. Reeb was previously the ninth Judicial District Attorney, but retired a year ago shortly after she launched her legislative campaign. She won the race in November but stayed with the “Rust” case.

Reeb’s dual roles as legislator and prosecutor caused a stir in the local legal community. George Heidke, a former attorney with the First Judicial District Attorney’s Office, told CNBC it was the first time in his 25 years as a New Mexico attorney that he had seen a sitting legislature double as a prosecutor.

Baldwin’s attorneys argue that Reeb should be removed from the case. “A prosecutor who also serves as a legislature could be pressured to make prosecutorial decisions that serve her legislative interests,” Baldwin’s attorneys wrote in a filing. Baldwin is an outspoken supporter of Democratic and progressive issues, making him a target for Reeb’s Republican peers.

The prosecutor’s office responded to that argument on Monday, saying such claims “are purely hypothetical and show which limb the defendant must step on to allege some sort of ‘interference or interference’.”

There are other complications too.

An aerial view of the film set at Bonanza Creek Ranch where Hollywood actor Alec Baldwin fatally shot cinematographer Halyna Hutchins and injured a director while firing a prop cannon on the film set of the film ‘Rust’ in Santa Fe, New Mexico, USA. in this frame from the October 21, 2021 television footage. The footage was captured on October 21, 2021.

KOB TV NEWS | Reuters

“I think everyone can agree that she’s unduly placed in two different branches of government at once,” Lisa Torraco, the New Mexico attorney representing Halls, told CNBC. “There’s a good reason for that: I’m donating to her campaign as a legislator, and now she’s the special prosecutor on my case.”

In September, Torraco donated $250 to Reeb’s campaign, believing that if Reeb won the legislature race, she would automatically withdraw from the Rust case. That didn’t happen.

“If I had known that, I probably wouldn’t have given her any money,” Torraco said.

In addition to Torraco, Carmack-Altwies, a registered Democrat, and Dennis Maez, the Halls private investigator, also contributed to Reeb’s campaign.

Torraco said there was no connection between her small campaign donation and Halls’ pleading. But according to Santa Fe attorney Day, “Looks matter.”

“When you donate money to legislators, you have to understand that people will have access to it and they’re going to be like, ‘What’s going on?'” he said. “That’s exactly why you don’t want a legislature who also doubles as a prosecutor.”

Heather Brewer, the prosecutor’s spokeswoman specially hired for the Rust case, confirmed Torraco’s donation. She added that Reeb’s “integrity could never be compromised by a $250 donation — or a donation of any size.

Gutierrez-Reed’s attorneys co-signed Baldwin’s motion to disqualify Reeb. The prosecutor’s office declined to comment on the application before submitting its response.

“A mistake in the first year of law school”

Aside from Reeb’s role in the legislature, local attorneys found it odd that Carmack-Altwies should even appoint a special prosecutor. In the past, when prosecutors did not have the resources to handle a case, they would turn to the Attorney General for help.

Instead, Carmack-Altwies demanded $635,000 from the New Mexico Treasury Committee and claimed that her office needed an additional attorney, a media liaison and other personnel to deal specifically with the “Rust” case, one said Writing that you on 13 30.

When asked by a member of the CFO if she had contacted the attorney general, Carmack-Altwies said she had not “specifically addressed this case,” according to the transcript of a hearing regarding her funding request. Reeb is the better option, Carmack-Altwies said, because she has “over 25 years of experience and this will be her only case for the next 12 to 18 months, which is intended.”

The state awarded the Attorney’s Office $317,750, about half of the original request.

Torraco said the charges Baldwin and Gutierrez-Reed face are among the lowest-level crimes in New Mexico.

“And they’re asking the Legislature for hundreds of thousands of dollars to prosecute them? It’s just absurd,” Torraco said. “They track fourth-degree crimes every day…why all the hype?”

The legal risk Baldwin faced was much higher until last month, when his attorneys challenged another prosecutor’s decision.

When Reeb first filed criminal charges, she included a so-called firearms enhancement lawsuit, which carries a possible five-year prison sentence. Baldwin’s attorneys filed a motion on February 10 to remove this amendment because it became law seven months after the fatal shooting and violated the legal concept known as “ex post facto.”

It was a “first-year law school mistake,” Day said. “As a prosecutor, it’s your duty to make sure you’re prosecuting the right law. And it’s embarrassing when that happens because it shows they don’t pay attention to details.”

Reeb reminded Baldwin’s attorneys of their legislative obligations in a Feb. 12 email after they objected to the amendment. She’s been “busy in session all week,” she wrote, and is now only able to take a closer look at the specifics of the weapons expansion.

Reeb soon after admitted that she misapplied the correction and dropped it from the case.

Media circus

The case has received significant media attention, which has continued due to press communications from Baldwin and the prosecution. Baldwin gave an interview to ABC’s George Stephanopoulos in December 2021. Carmack-Altwies and Reeb have both appeared on CNN and Fox News.

In addition, Brewer, the spokesperson specifically hired for the Rust case, has made several heated statements about Baldwin and his attorneys on behalf of the prosecution.

Camerawoman Halyna Hutchins can be seen in this undated handout photo obtained by Reuters on October 23, 2021.

Nursing Studios | via Reuters

Following the Feb. 10 motion to reduce firearms enhancements, Brewer told CNBC that the prosecutor’s office was intent on holding anyone, “even celebrities with outlandish attorneys,” accountable under the law. Almost two weeks later, when Reeb dropped the amendment, Brewer said in a statement that the charges were dropped “to avoid further contentious distractions by Mr. Baldwin and his attorneys.”

“The priority of the prosecution is to ensure justice, not to ensure billable hours for metropolitan attorneys,” Brewer added.

Brewer has also implied that Baldwin’s attempts to remove Reeb from the case are aimed at diverting focus from Baldwin’s alleged criminal conduct. “Mr. Baldwin and his attorneys can use any tactics they wish to distract from the fact that Halyna Hutchins died on the ‘Rust’ film set as a result of gross negligence and a reckless disregard for safety,” Brewer said in a public statement.

The American Bar Association advises attorneys against making public statements that could harm a jury in a criminal trial, especially when it involves the “character” or “reputation” of the defendant.

“Prosecutors have to walk a very fine line between what they can say publicly,” said Day, the local attorney. “You don’t want to be accused up front of poisoning the jury pool. And that could certainly be an issue here.”

Rachel Maddow dismantles Georgia GOP for making an attempt to avoid wasting Trump

Rachel Maddow showed Georgia Republicans are willing to destroy democracy to save themselves and Trump from prosecution.

Video:

Maddo says:

And I don’t know, maybe that would be easier to see if it happened in another country. And you know, maybe the leader of your party is still going to be charged in other jurisdictions where he’s under investigation, like the federal level, or in upstate New York where he’s under investigation. Maybe he will, maybe he won’t. None of us know. But in the one place where he’s being criminally investigated and his party has full control of the state government, they’ve just decided, for the first time in the state’s history, that it’s in their own power to remove prosecutors from the country say of their own accord in the midst of their duties. And yes, this is a story about Georgia, and yes, this is a story about Trump and the potential charges he faces. But this is a whole new step for us as a country. This is new for us as a democracy.

This is not baiting the investigators. We’ve seen that before. And berate people and even single out individuals in the law enforcement system to try and make enemies of them. As bad as that is, we’ve seen it all before. This not only delegitimizes the entities verbally and politically. These are bad things to do.

But this is more.

stick and stone, right? But doing so will dismantle the workings of the legal system so that it will no longer work against him. This is not a resolution denouncing a prosecutor who could bring charges against Donald Trump. That gives the Republicans, that’s the Republicans voting to give themselves the power to unseat a prosecutor who’s acting in ways they don’t like because they’re on the brink of possibly filing charges against him. This passed the Georgia state legislature tonight and will soon be on its way to the governor. For Georgia yes, but for us as a country this is a milestone.

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Republicans are ready to destroy Georgia democracy to save Trump and their own skins. The idea that Georgia Republicans will give themselves the power to unseat prosecutors who are elected officials if they do something Republicans don’t like.

Maddow was right. What Georgia Republicans are trying to do is a threat to democracy. Georgia GOP would rather destroy democracy than see Trump indicted/

Jason is the managing editor. He is also a White House press pool and congressional correspondent for PoliticusUSA. Jason has a bachelor’s degree in political science. His thesis focused on public policy with a specialization in social reform movements.

Awards and professional memberships

Member of the Society of Professional Journalists and the American Political Science Association

Longevity knowledgeable who studied 110-year-olds on how people beat ageing

As a postdoctoral researcher at Stanford University, Kristen Fortney used bioinformatics to study the genetics of supercentenarians — people who live to the age of 110 and beyond. Now she is at the forefront of biotech efforts to turn longevity science knowledge into medicine. As CEO and co-founder of BioAge, a clinical stage biotech developing a pipeline of treatments to extend healthy lifespan by targeting molecular causes of aging, Fortney is working directly on a biological challenge that has attracted some of the biggest minds, and deepest pockets, in the world.

There’s a long history of wealthy people directing their financial resources where they can make the greatest positive impact on human health, she noted in a recent interview with CNBC ahead of its upcoming Healthy Returns virtual conference. Examples include the Chan-Zuckerberg Initiative, the Broad Institute, the Paul Allen Institute for Brain Science, and the many philanthropic efforts devoted to cancer research. BioAge investors include Andreessen Horowitz, Redpoint, AARP Foundation, Kaiser Foundation Hospitals and Khosla Ventures.

Fortney says to address the greatest number of people through medical innovation, aging is a good target. What’s more, aging biology is a unique lever point to delay the incidence of multiple diseases at once, and longevity science has arrived at the point where it is ready to start translating knowledge into therapies.

The following interview, conducted via phone and email, has been edited for length and clarity.

CNBC: VCs and pharmaceuticals are starting to pay more attention to the science of longevity. Why the sudden shift in interest?

Fortney: Aging is the primary cause of many chronic diseases, including devastating illnesses like cancers and Alzheimer’s. We’ve known that for a long time, but in recent years, science has advanced to the point that we’re confident we can do something about it. Researchers have discovered multiple interventions that can increase healthy longevity in animal models, showing that healthspan can be extended. At the same time, technological progress has given us unprecedented understanding of human aging, as well as the ability to translate this knowledge into therapeutics. Targeting aging will enable us to treat disease in entirely new ways. As awareness of that potential grows, it is attracting intense interest in the sector.

Sign up today for the sixth annual Healthy Returns Summit. We’re bringing in key leaders and experts to discuss medical innovations, drug breakthroughs, life science investments and more. Register today.

CNBC: What area of longevity is your startup focused on?

Fortney: BioAge takes a “human data first” approach to understanding aging, learning about the underlying mechanisms of healthy longevity from humans who are already aging well. People age at different rates — some die of an age-related disease in their 50s and 60s, whereas others live into their 90s and beyond in good health. We use AI and machine learning to analyze the distinctive molecular features of people who live the healthiest, longest lives, and then use that knowledge to develop therapies that could help everyone age more successfully. Because we’re using modern technologies to get a comprehensive molecular picture of aging, we are able to discover many different aging mechanisms, rather than being limited to a handful of targets chosen in advance.

CNBC: Tell us how you incorporate AI into your drug pipeline.

Fortney: AI and ML are the key technologies that enable us to pinpoint the molecular differences that predict healthy versus unhealthy aging. Our discovery process begins with our aging cohorts — precious samples collected from thousands of people over decades — coupled with detailed records of their health and mortality, which we access through exclusive partnerships with unique biobanks around the world.

We analyze each sample using modern omics technologies, measuring tens of thousands of proteins, RNAs, and metabolites. The resultant datasets are huge and complex, so we use modern AI and statistical techniques to sift through the subtle patterns and identify the biological pathways and molecular factors underlying healthy longevity. Ultimately, we’re looking for the pathways that distinguish the most successful agers. The proteins that play key roles in these pathways become our drug targets.

CNBC: How might BioAge’s approach to developing therapeutics slow down or prevent age-related disorders?

Fortney: Because aging drives disease, targets that are related to aging will help combat disease. A central aspect of our approach is discovering pathways which, when they’re active in certain ways, result in a healthier person. So, drugs aimed at these mechanisms have the potential to be curative for some diseases and also slow or prevent them.

In the near term, we’re developing drugs to treat specific diseases, but in the longer term, we’re envisioning a path similar to what happened with the statins. They were originally approved for a narrow indication, familial hypercholesterolemia, but over time they were applied more and more broadly, and today they are used widely in basically healthy people to prevent cardiovascular disease. Our muscle aging drug that we recently tested in a successful Phase 1 trial is a great example of a clinical program that could follow a similar path.

CNBC: How do you apply machine learning methodology into studies?

Fortney: We believe in learning as much as possible from our clinical trials, not only about the primary indication but also about aging itself. We achieve this using biomarkers that we build with our machine learning approach. Let me give an example: Our ML analysis of our aging cohorts yielded biomarkers of long-term physical function — sets of proteins whose levels predict your future functional status, walking speed, grip strength, etc.

In a recent clinical trial for muscle atrophy, we showed that our drug triggered changes in these biomarkers that mirrored what we see in people who retain high levels of physical function throughout their lives. So even in a short-term study, we were able to learn about biomarkers that correlate with long-term functional impacts over decades. This shows the power of our ML methods to reveal new aging biology and confirm that our drugs are exerting beneficial effects on the aging process.

CNBC: Tell us more about BioAge’s clinical programs on muscle aging.

Fortney: We recently completed a successful Phase 1b trial of the lead drug in our muscle aging program. The drug, BGE-105, mimics the effects of apelin, a small peptide that plays important roles in muscle regeneration. Our aging cohorts revealed that people with higher activity in the apelin pathway lived longer and maintained better muscle and cognitive function as they aged. In the trial, BGE-105 prevented muscle atrophy in people over 65, and this has implications for a large number of medical conditions with high unmet need.

We’re now moving forward with multiple Phase 2 trials of this drug, one to prevent severe muscle atrophy in ICU patients, and another to combat muscle loss in patients being treated for obesity. Over the longer term, we want to go after sarcopenia [age-related loss of skeletal muscle mass and strength] itself.

CNBC: Why is the prevention of muscle atrophy so important? And so far, no therapies have been discovered to prevent muscle aging, correct?

Muscle atrophy decreases mobility, robbing older people of their autonomy and dignity, and often forcing them into nursing homes. In addition, declining muscle function compounds the risk of falls, which are a major cause of accidental death in older people. Frailty affects 15% of the population over 65, more than 8 million people in the U.S. alone, and some degree of muscle atrophy is a nearly universal aspect of aging. But despite its prevalence, we have no effective treatment, so this is an enormous unmet medical need that we are hoping to address with our clinical programs.

CNBC: You use proprietary human samples with detailed health records. Explain how you use this to map out molecular pathways.

Fortney: In addition to biological samples, our biobanks also contain rich health data, not just how long the donors lived and when they got sick, but functional measures relevant to everyday life. Using these two kinds of information together, we can interrogate the molecular profiles generated by our omics analyses and identify the kinds of changes that predict, for example, a reduction in grip strength or declining cognition. This approach gives us the unique ability to connect molecular pathways to health and disease.

CNBC: Turning to brain aging, what do your studies show on this front?

Fortney: Like muscle loss, cognitive decline is a nearly universal aspect of the aging process, and can range in severity from mild memory impairment to severe illnesses like Alzheimer’s. Our ML analyses of our aging cohorts revealed multiple pathways that play important roles in brain aging. For example, higher activity of a cellular machine called the NLRP3 inflammasome was correlated with more rapid decline in cognitive function with age. This implied that if we could decrease inflammasome activity, we could slow some aspects of brain aging and treat or even prevent age-related neurological diseases.

CNBC: Can you explain more about your focus on NLRP3 inhibitors in brain aging, what they are and what progress you have made using AI data.

Fortney: Like many aging targets, NLRP3 is at the nexus of multiple disease processes. Chronic activation of the NLRP3 inflammasome with age contributes to pathologic inflammation, driving disorders in the brain as well as the peripheral tissues. We reasoned that if we could inhibit the activity of NLRP3, we could bring that age-related inflammation under control, so we screened through billions of compounds to identify a new class of molecules that can do just that.

A particularly exciting feature of our new NLRP3 inhibitors is that some of them can cross the blood-brain barrier and are therefore suitable for applications related to brain aging. Other molecules in this new class of inhibitors will be used for targeting inflammation in the eye or other tissues outside the nervous system.

When these drugs are ready for clinical trial, the biomarkers related to cognitive function that we built using our AI platform will help us with patient selection and assessing the drug’s effects — and as in the trial for our muscle atrophy drug, we’ll leverage the biomarkers to learn as much as possible about the aging process in parallel with the primary endpoints of the studies.

CNBC: What key partnerships do you have and what are you doing together?

Fortney: Human data and human samples are central to everything we do at BioAge. However, human aging takes a long time, so we need some way to follow aging in individuals that doesn’t require us to wait 80 years to collect our data. We solved this problem by establishing exclusive partnerships with multiple aging biobanks, which contain samples collected longitudinally from healthy people over decades of follow-up. These resources provide invaluable insight into the molecular bases of healthy longevity.

For example, last year we announced a partnership with Age Labs, a diagnostic company based in Norway, that allows us to analyze a huge biobank collected from more than 100,000 volunteers over more than 25 years of aging. The data generated by the partnership will dramatically accelerate our ability to discover new aging mechanisms and to identify, develop, and commercialize drug targets for age-related disease. The Age Labs collaboration is just one of several active partnerships, and more news in this area is coming soon.

CNBC: Where do the investable opportunities lie? Unlocking ways to prevent diseases? Or sub-investable areas like geroscience, age-tech, regenerative medicine, longevity fintech, longevity fem-tech?

Fortney: It’s important to remember that we’re still in the early years of longevity biotech, and we expect that the number of potential mechanisms as well as applications to grow substantially over time. In the near term, we believe that studying aging biology will give us new drugs for diseases where there’s a high unmet need. Over the longer term, we’ll be unlocking ways to prevent disease from arising in the first place.

To go back to the analogy I made earlier, the statin drugs evolved into what are essentially preventive medicines for heart disease, and we can envision medications based on aging biology that are eventually used to prevent huge blockbuster diseases of aging with very high prevalence. Imagine a drug that could prevent muscle loss and thereby basically eliminate frailty, or that could dramatically slow cognitive decline. The availability of drugs like that could revolutionize healthcare — not to mention helping older people to live full, independent lives. 

Twitter Responds To Alleged Chris Rock Jokes About Will Smith Slap

Nearly a year after the Will Smith slapgate incident at the Oscars, Chris Rock is reportedly incorporating some jokes about the affair into his recent stand-up routines. However, various Twitter users don’t seem to be here for his alleged antics!

Chris reportedly joked he watched Emancipation to watch [Will] be flogged’

Speculation erupted just before the comedian special Chris Rock: Selective Outrage was livestreamed on Netflix. Numerous reports indicate that Chris prepared for the special by including material based on the Oscars incident in his other shows.

RELATED: Chris Rock calls Will Smith’s apology video a ‘hostage’ video

The New York Post reports that Chris took the stage at a show and mentioned that he only saw Emancipation – a film in which Will Smith plays an enslaved man – to “watch.”[ing] he will be flogged.”

“I was watching Emancipation the other day just so I could watch him get flogged.”

According to the Wall Street Journal, Chris also referenced his and Will’s respective film roles to acknowledge the physical differences between the two.

“The thing people want to know… did it hurt? Hell yes, it hurt. He played Muhammad Ali! I played Pookie [In New Jack City]. Even in animation I’m a zebra, he’s a frigging shark.”

He also referenced Will’s music career, adding, “I was hit so hard I heard ‘Summertime’ ringing in my ears.”

That sentiment was further refined with additional comments reported by CNN.

“Will Smith is a great guy. I’m not. Will Smith doesn’t wear a shirt in his films. If you see me in a movie having open-heart surgery, I’ll put on a sweater.”

Chris Rock has polished up footage on Will Smith ahead of his live performance on Netflix on Saturday https://t.co/hazIXLNGcl pic.twitter.com/07P6o9ro8r

— Philip Lewis (@Phil_Lewis_) March 2, 2023

Twitter users react to the Chris Rock speculation

In response to these reports, people on Twitter have started expressing their thoughts on the matter, and most are not very happy with Chris. Users were particularly disappointed with his comments on emancipation.

Check out some reactions below.

chris rock poked fun at a black woman on national tv, became a victim after getting what he deserved and now spends his free time enjoying watching a black man flogged as a slave. lol https://t.co/fqCpvr1SxJ

— maleficent ✰ (@houseofphoton) March 3, 2023

Chris Rock comes back a year later with Will Smith jokes pic.twitter.com/4iK7XTQ9Ru

— Tez💜 (@JoeSweatpants) March 3, 2023

Chris Rock has been talking about slapping the Oscars since the Eisenhower administration. Apparently Will Smith didn’t slap his ass hard enough… pic.twitter.com/LojBN25b9r https://t.co/I3ea94ylNT

— 𝓦𝓪𝓵𝓮𝓮 🖤 (@SpicyAABoy) March 3, 2023

And somehow people think Will Smith is the problem?!

— AKA (@GuyWhoConquers) March 3, 2023

People act like Chris Rock hasn’t dabbled in this kind of nonsense in the last ten years.

Why is everyone acting like the words that led to “The Slap” were the first shit like this and not the last straw for Smith? https://t.co/CpIEMPXMEp

— Imani Barbarin, MAGC | Crutches&Spice ♿️ (@Imani_Barbarin) March 3rd

In addition to criticizing Chris’ comments, the critics also took the opportunity to address a past shady moment involving rock and some white comedians.

Chris Rock had two white comedians use the N-word in front of him and laughed at him being a loser https://t.co/QCi1zsX0Cl

— Gloria Alamrew / Gloria 🇪🇹🌻 (@GloriaAlamrew) March 3

Since Chris Rock is trending, watch him make Louis CK and Ricky Gervais poke fun at black people and use the N-word.

Jerry Seinfeld was the only one who said to stop.
pic.twitter.com/RG0D93D43C

— 🕯️🔪🥀 ʇoN 𝕵𝖔𝖘𝖎𝖊 𝕲𝖗𝖔𝖘𝖘𝖞🪬🔮𝐵𝐿𝑀•ACAB (@NotJosieGrossy) March 3, 2023

Chris Rock been lame since he said he let his white friends say nigga and JERRY SEINFIELD had to check him out!!

– away …. 🌙 (@TeeChereaa) March 3, 2023

However, not everyone was opposed to Chris Rock speaking out about the “Slapgate” incident since

I find people who tell Chris Rock to walk away from something that happened to HIM wild. I understand that you all love Will Smith, but Will literally slapped him like in real life. He can talk about this shit as long as he wants. It happened to HIM, not to all of you.

— Tired Black Woman Geek (@toomuchtelly) March 3, 2023

What do you think of the speculation and the backlash that followed?